First flow the intersection of virus and important albumen studies and obtains the break-through

First flow the intersection of virus and important albumen studies and obtains the break-through
First flow the intersection of virus and important albumen studies and obtains the break-through
It is reported ' Reporter Li TianShu) A few days ago, Ins of Microorganism,Academia Sinica announced to the outside, through the brainstorm of nearly one year, to two important albumens of the surface of 2009th first type H1N1 influenza virus - -Hemagglutinin (HA) With neural amino acid glucoside enzyme (NA) Research make importance break-through. The research results about HA are published on magazine of " protein and cell ", the research results of NA are published on magazine of " nature - structure and molecular biology " online recently. Influenza virus causes seasonality, epidemic influenza and accidental great prevailing causing the son of cause of disease of influenza, there are two kinds of important bag membrane albumens on the surface of virus: HA and NA. 2009 first flow virus it gets HA to be 1 type with NA 1 type making up. The functions of two kinds of albumens are different. HA responsible for discerning the saliva sour receptors of the surface of night chief cells, assists the integration of bag membrane of virus and host's cell membrane, play an important role while the virus channels into the constellation chief cell. HA is still an important surface antigen, antibody of resisting HA can neutralize influenza virus. NA responsible for, remove cell receptor terminal saliva in combination with HA sour, contribute to preventing the virus from assembling. The intersection of Ins of Microorganism,Academia Sinica and high researcher, seminar of good fortune, choose 2009 first flow the intersection of virus and the intersection of model and malicious HA and NA of go on discovering as target, it is highly similar that it and 1918 click in the HA whole structure and antigenic location of influenza virus, but differ significantly with seasonal influenza. The researcher infers, 2009HA can be neutralized by 1918 influenza patients or serum of the person who carries virus. View this explain young people flow, exchange sense to 2009 first, but the elderly possess strong the intersection of resistance and this phenomenon. The seminar still finds, 2009HA has enhanced alkaline districts, can improve the virus and infect strength. But 2009HA the intersection of N279 and location compared with seasonal influenza and 1918HA, have one the intersection of candy and base location order near the alkaline district. This candy base location can hinder the function of alkaline district to order, and may interfere with antibodies to discern, can cause virus virulence to weaken, causing the fatal character to weaken to constellation chief cell, virus virulence reaches the dynamic equilibrium, thus help oneself amplifying and infecting in a large amount in the constellation subject. The relevant medicine flows to first in this research to research and develop and offer the new thinking.


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