After poisonous one of first type H1N1 influenza has come

After poisonous one of first type H1N1 influenza has come
After poisonous one of first type H1N1 influenza has come
Staff reporter Wang LeMin After going through waiting, World Health Organization can offer poisonous one of first type H1N1 influenza virus at last. This lets everybody see the listing dawn of first type H1N1 influenza vaccine. What kind of course first type H1N1 influenza vaccine is ground and returned to need passing? As to this, reporters have interviewed relevant person and expert. One has been different that our country has already made good preparations for abundant technology and made poisonous one of vaccine and poisonous from the virus that is isolated in patient's body directly, the ones that need to be trained specially and transformed and took shape in the laboratory lower the toxic special virus one. Because poisonous of quantity constructed for the first time are rare, only regarded as " standard text " distributed to every vaccine manufacturing enterprise ,Known as " Poisonous kind " . "It is no longer a difficult problem to research and develop first type H1N1 influenza vaccine, only need to use craft route and quality criteria of vaccine of bird flu according to people, change poisonous one of H5N1 bird flu virus into poisonous one of first type H1N1 influenza virus. " The vaccine expert Yin WeiDong introduces, before influenza comes greatly and prevailingly, the scientist is unable to foresee from which kind of virus it will caused. So, must regard new variation influenza virus which the human body has never met as the model to vaccine with big and prevailing influenza, finish vaccine production technology route and quality criteria, confirm antigenic content of vaccine and component, and arrange relevant data such as the antigenic content of vaccine, immunity are original, security, rendering a service,etc. as the register-file, submit administrative authority to file and register, get the official written reply. National the intersection of food and medicines supervise administration bureau medicines register the biologicals Yin HongZhang, division chief of of the department and introduce, with the improvement of the scientific research level of our country, our country has already done abundant technological preparation well to vaccine of big popular influenza. On the foundation that big popular influenza vaccine produced in the whole world is generally suitable for the crowd 18 years old to 60 years old, our country directs against these two kinds of special crowds of old man over the child under the age of 18 and 60, launch special technical research, so as to ensure when great popular influenza comes, the crowds of different age brackets can all be protected effectively. This kind of research still belongs to the first time in the world. China disease accuse of the intersection of centre and scientific and technological XiaoPing Dong, division chief of place, say our country to influenza technology research and development of vaccine very much ripe already in route. Since finding the bird flu case in 2004, the Ministry of Science and Technology organizes the project of researching and developing vaccine. Through directing against the research of H5N1 bird flu virus during these years, China's disease accuses of centre's and Beijing department's revitalizing the technological route that the company has already finished all new vaccine and studied and registering and examining and approving the route, once our country is produced and uses poisonous one of first type H1N1 influenza virus, can organize researching and developing and producing rapidly. Dong XiaoPing says, it is a very complicated course that vaccine is produced, need one test period, including essential clinical and zoological test. Our country get after the malicious, if it is smooth, 3 4 months expected to put the first batch of vaccine into operation. It is reported get first type the intersection of H1N1 and influenza virus behind the malicious, vaccine manufacturer take one or two separate, the malicious one of virus grows fast month also usually, in order to obtain the largest output, could really begin vaccine production. National food medicines supervise Yan JiangYing, press spokesman of administration bureau, expressing, national the intersection of food and medicines supervise administration bureau make, work well new poisonous of for producing first type H1N1 influenza vaccine special the intersection of examination and approval and work preparation already. Relevant departments such as Nat'l Pharmaceutical Biological Products Control Inst,etc. have already made the emergency operation scheme, in order to do vaccine well and criticize and issue the work fast, accurately. A personage that national food medicines supervise administration bureau medicines register the department reveals, except that the department of Beijing revitalizes the company, manufacturing enterprises of several of domestic vaccine are stepping up researching and developing first type H1N1 influenza vaccine, and made certain progress. Influenza virus makes a variation quickly, if first type H1N1 influenza virus morphs, is vaccine developed now still used when the time comes? WHO has shown, predicts now the change of first type H1N1 influenza virus is early before this, but is monitoring any change of the virus closely about the organization, will find the virus presents the great change in the future, will make the fast reaction in view of the above. Chen Zhu, minister of Ministry of Public Health, says while giving a lecture on genetic science and industry development summit forum of China held on June 2, the view of international medical circle and scientist of our country shows, present first type H1N1 influenza virus variability is not very great, that is to say that will not turn into the virus with very strong lethality quickly temporarily, it is possible for this to offer in order to prevent and cure first type H1N1 influenza through vaccine too. WeiDong Yin say we race in variation of virus, confident of, deal with variation that future might appear. Sort out to still wait to confirm influenza can be divided into two big classes, one is seasonal influenza in first type H1N1 influenza, influenza that one kind great prevails. And mode of production of vaccine look at first type the intersection of H1N1 and influenza, belong to which kind of make really. The face river Ying introduces, as to seasonal influenza, WHO will collect the poisonous one of influenza in different influenza centres of the whole world every year. Then, it may be poisonous one of any one that WHO will organize experts to assess the next seasonal influenza, after deciding poisonous one of the seasonal influenza, distribute poisonous one into country and enterprise of vaccine production of influenza in every February. After putting on record in the responsible institution, manufacturing enterprise can produce vaccine. And to this first type H1N1 influenza, depend on how WHO assesses it. If WHO assesses it as seasonal influenza, the responsible institution produces the procedure to do according to vaccine of seasonal influenza, if WHO assesses it as great popular influenza, goes on according to the big prevailing influenza vaccine. At present, what each side needs to wait for is that WHO judge what kind of influenza this is, its properties will determine the production of vaccine. Yan JiangYing says, national food medicines supervise the administration bureau doing all preparation well in earlier stage, put vaccine into production after WHO distributes the poison one. This mainly includes quality controlling, the security supervision of production and investigation of enterprise's production capacity,etc. that are produced. Must monitor the vaccine security closely if poisonous one of first type H1N1 influenza virus that the egg fosters makes good progress, vaccine manufacturer and relevant department will set about paying testing in testing vaccine, and this is concerning the safe in Volkswagen a very important link. An expert says to reporters, that influenza not forming the large-scale epidemic situation that broke out in 1976 draws the dispute to security investigation of vaccine. Influenza vaccine researched and developed and come into operation that time was verified later that there will be perhaps caused the injector to be paralysedding of 1 / a million (Green - syndrome in Bali) . He says, has something to do First type the intersection of H1N1 and the intersection of influenza and security of vaccine, confirm, appear Green after the injection - how loudly, etc it will be risk, Bali of syndrome yet either at present, so before and after monitoring vaccine and going on the market closely? Step on ��'s bath? Meanwhile, as to first type H1N1 influenza vaccine while developing, some concrete amynologic data have not been fixed yet either at present, for example offer the immunity to protect, how long necessary vaccine pharmaceutical count, separate to inject second pharmaceuticals,etc.. Who is suitable for after using first type H1N1 influenza vaccine of vaccine to list preferably, who are suitable for inoculating preferably? The suggestion of WHO is decided by various countries' proper motion. But WHO will follow the development with great and prevailing influenza in time, after obtaining enough information, will define who are the high-risk group of the first type H1N1 influenza, it decides the crowd who inject vaccine preferably that various countries can consult, in order to make the limited vaccine supply give full play to the protection result. Yin WeiDong shows, before seasonal influenza comes, the key recommendation crowd of vaccine inoculation included: Old men, chronic disease patients and valetudinarians, the medical staff members of health organ especially children of front man, primary school and kindergarten over 60. And this H1N1s first type influenza, the infeted more to young people, medical personnel, customs officer, quarantine personnel,etc. should list by high-risk group in, should inoculate at first. Yin WeiDong says, can resist the invasion and attack of influenza effectively within one year after inoculation as to vaccine of seasonal influenza, first type H1N1 influenza vaccine is the same, usually will produce antibodies in the human body within 2 weeks after vaccine inoculates, can produce protective action after from 45 days to 2 months, and the protective antibody can last more than 1 year in the human body. Yan JiangYing says, our country is setting up happening suddenly emergency system, strategic reserves and other a series of epidemic situations of the public health event are reporting the respect is more complete. If there are condition and ability with vaccine production of big influenza of enterprises, national food medicines will supervise the administration bureau in accordance with the regulation, according to the procedure, take the standard to examine and approve it. Meanwhile, will do the reserve work of vaccine of big popular influenza well. But a public medical and health expert says to reporters, when influenza spreads, vaccine is one of the most effective shelter weapons. It can have vaccine but can't be thought " let out a sigh of relief, even once and for all " . As to individual, it is the key to preventing and controlling disease to form good life and hygienic habit forever; As to society, the effectual public health is strategic, cut off and propagate the route, controls and infects the source and protects comprehensive measures such as more easily infected group,etc. effectively, it is the scheme getting a permanent cure. Chain the first type H1N1 influenza vaccine production procedure Culture: Draw the chicken embryo of the 7th age from the egg, " plant " the virus of source Get in the allantois of chicken's embryo. Breed: Put chicken's embryo into the airtight, aseptic hatching case with thermostatical 35 ��, guarantee the normal development of chicken's embryo, enable a fast reproduction of poison. Collect: 3 days later, pluck the virus good in development from chicken's embryo. Deactivate: Use the formalin, through deactivating the craft, remove the infection of the virus. Filter: Filter too many proteins, keep antigen useful to immunity - -Hemagglutinin ( H5) With neural amino acid enzyme ( N1) ,Namely virus original liquid. Make: Dilute, add adjuvant, make vaccine finished product.


|