First have two mechanism of having illness coming on while being overbearing

First have two mechanism of having illness coming on while being overbearing
First have two mechanism of having illness coming on while being overbearing
It is reported Shanghai Communications University medical college subsidiary Rui Jin hospital unites with the southern research center of the national human genome, adopt the related analysis (GWAS) of the whole genome Wait for advanced genome-based technologies, find first is overbearing there are two kinds of different morbidity mechanisms. The relevant research results were issued on magazine of " natural science of heredity " a few days ago. It is a kind of common organ specific one's own immune disease that first is overbearing, it stresses the characteristic is that there is thyroid gland that stimulates the hormone receptor antibody (TRAb) in serum . First of crowd of our country is overbearing the ill rate is about 1%, it is estimated that nearly there are 13 million patients. Employ and resist the thyroid gland medicine (ATD) Treating this disease alreadies have a history of nearly 50 years, it is still a kind of safe and most effective treatment so far. However, quite a few of patient treatments recur after relieving, the condition becomes more serious while recuring, and curative effect is not good. As to the difficulty that this disease exists in treating, need qualification and application of the molecule mark urgently. Researchers utilize the relevant sample of disease accumulated for many years, adopt GWAS technology, have carried on further investigation on overbearing crowd of big sample first, and found first new of two overbearing and exchanged the induction to click, therefore has discerned two relevant genes, one of these had not reported yet before (the research group named it as GDCG4p14) ,Meanwhile, these two genes will be influenced and regulated the immune T cell function, it may be that it exchange the sense gene that first new is overbearing and pathogenic. The more meaningful one is, researchers find, there may be two kinds of different morbidity mechanisms in first overbearing patient. People know, first is overbearing after treating, the thyroid gland stimulates the hormone receptor antibody (TRAb) Positive continuously, an important prediction index that recured after medicines stopped. As to after drug therapy, thyroid gland stimulate hormone receptor gene attitude and the intersection of TRAb and antibody it turns negative patients to be independent much, but is closely related with with the continuously positive patient. This research has offered a kind of valuable means for clinical treatment, for two kinds of patients of more accurate differentiation, and contribute to guiding first overbearing clinical application. (Zhang MiLi)


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