North American poisonous one has four major characteristics in first type H1N1 influenza virus

North American poisonous one has four major characteristics in first type H1N1 influenza virus
North American poisonous one has four major characteristics in first type H1N1 influenza virus
It is reported ' Reporter Li TianShu) A few days ago, the study on North American poisonous one of first type H1N1 influenza virus of the researchers of Ins of animal,Academia Sinica made the break-through. Researchers find these North American poisonous homologies are very close, they have 4 characteristics: Do not have a characteristic of high pathogenic influenza virus; Have obvious affinity to people; Have lower pathogenic strength to people; Sensitive to neural amino acid enzyme inhibitor medicine, but have resisting nature to the alkane amine medicine of Buddha's warrior attendant. Study the virus molecule characteristic and know the pathogen, to understanding first type H1N1 influenza virus is very essential. Research group of the leader, researcher He HongXuan of seminar of epidemic disease of wild animal of Ins of animal,Academia Sinica, g resistance location order analyzing analysis, the intersection of protein and the intersection of amino acid and array, the intersection of candy and the intersection of base and some location and drug resistance location order analyzing. The result indicates, it is that one comes from recombination one of different host, different region; Poisonous characteristics not having high pathogenic influenza virus in North America that HA protein amino acid array analysis shows; NS1 albumen and PB2 protein amino acid array indicate to have obvious affinity to people, but have lower pathogenic strength to people; The homology modeling of M albumen indicates to have structural characteristic of resisting the alkane amine medicine of Buddha's warrior attendant, it is still sensitive to the neural amino acid enzyme inhibitor medicine that NA albumen array analysis shows. Researcher point out result of study this tell people first type H1N1 this influenza have obvious infection to people, insensitive to alkane amine medicine of Buddha's warrior attendant, but the pathogenic strength to people is relatively low, " reach Philippines " to neural amino acid enzyme inhibitor medicine ,etc. sensitive still,can defend not can manage controllablying.


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