Neural stem cell move mechanism find in brain

Neural stem cell move mechanism find in brain
Neural stem cell move mechanism find in brain
Tokyo, July 29 (Xinhua) ' Reporter Lan JianZhong) The municipal university researchers of Nagoya of Japan publish the article to point out on the " neuron " network edition of the scientific magazine of U.S.A. of the 29th, they at not carrying on experimenting with mouse, find neural stem cell that produce newly in the brain its in mechanism that move under brain. This discovery may contribute to developing and treating the brain the new method of brain disease of blocking up etc.. Before this, researchers have already known in the district under the ependyma of the ventricles of the brain of adult mammalian side the neural stem cell mainly exists, in in normal cases " Lie dormant " The state, in cases the brain is damaged etc. specially, the neural stem cell can proliferate, move and divide into new neuron and neuroglia cell, then different position in brain play a corresponding role, make, regenerate or develop, succeed related to the fact that sense of smell,etc. feels cell position that damage. But, how is it to move in the brain that these neural stem cells gathered in cells, not been understood clear by the expert all the time. A research group that and prolongs and lead of medical professor pool finds the regeneration of the municipal university of Nagoya, the neural stem cell which the mouse produces in the brain newly is while passing and distributing the widest star-shaped colloid extraellular space in the brain, will secrete one and is called " SLIT " Protein,after not stimulating by this kind of protein,will shrink back astrocyte part when oneself is protruding, thus abdicate a passway for the neural stem cell and make the neural stem cell move in the brain. The astrocyte distributes the most extensive kind of cell in the mammalian brain, what this cell is stretched out a lot of long and the protruding thing of branching is filled with among various nerve cells, play a role in supporting and separating the nerve cell. Researchers then make the neural stem cell of the mouse unable to secrete " SLIT " through operating Protein, found finally the movement speed of the neural stem cell became very slow, the astrocyte does not give way for it again either, it means it is exactly " SLIT " Protein makes the neural stem cell move in the brain smoothly. In the research at the next stage, researchers of the municipal university of Nagoya will try to develop and let the neural stem cell be moved over high-efficiently into the new method to appoint the position, in the hope of treating the brain the brain of blocking up etc. better.


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