The new cause of disease of male sterility is announced

The new cause of disease of male sterility is announced
The new cause of disease of male sterility is announced
It is reported ' The reporter reporter Min JianYing and Hu DeRong) The king of medical college of Shanghai Communications University casts steel in many R D institutions inside and outside seminar the United Nations of a professor, tackle key problems through the cooperation of nearly 5 years, utilize the mammalian model, has verified the causality taking place between development in Kif18a gene mutation and sperm. Thesis of this research is in publishing magazine of " gene and cancer " in U.S.A. in the form of cover story on January 27. The expert thinks, this research results not merely contribute to some important theoretical questions that expound the human sperm takes place in development, and have important theory and actual meaning in male healthy reproduction, sterility treatment and research and development of the technology of male birth control. It is introduced, Kif18a gene is a new member who drives the albumen family, are playing indispensable important function while development takes place in the sperm. The body of spindle is a important cell device formed in the course of cell division, it can draw the chromosome and move to cell the two poleses, make the chromosome get average allocation. The experiment of the scientific research personnel of this project proves it causes the body of spindle in the course of cell division to form the obstacle directly that Kif18a function is lacked, the spindle fiber little tube is distributed and it is assigned that dynamic disorder, chromosome set are unusual and can't be equal, cause sperm's cells and split and move towards the death normally finally. Further discover, Kif18a gene can combine the albumen BubR1 and Cenp-E of check point of body of spindle in sperm's cell division, the albumen level of the two participates in his function's regulating, offer necessary motive force for sperm's cell division after being steady, and keep body structure of the spindle and function normal, enable sperm's cell division to finish smoothly. Finally, scientific research personnel, through animal's model " the operation is excised " Kif18a gene makes the male experiment mouse become " Eunuch's mouse " ,Shown as little mouse's sterility of adult male, testis withering, sperm lack. A professor says when being interviewed by reporter that Wang casts steel, the discovery of Kif18a genetic function, study, open up new direction for male the intersection of sterility and cause of disease, cause of disease diagnose, treat and male the intersection of birth control and development of new technology bring hoping for male sterility probably. It is Shanghai Communications University medical college subsidiary Rui Jin hospital to join many R D institutions both at home and abroad that this project studies separately, medical college of New York University, healthy scientific research institute of Chinese Academy of Sciences, southern model organism research center of Shanghai,etc..


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