Cancer cell split reason have new explanation limitlessly A kind of nucleoprotein and an enzyme helps make it from bad to worse

Cancer cell split reason have new explanation limitlessly A kind of nucleoprotein and an enzyme helps make it from bad to worse
Cancer cell split reason have new explanation limitlessly A kind of nucleoprotein and an enzyme helps make it from bad to worse
Berlin, December 21 (Xinhua) ' Reporter Guo Yang) The most prominent characteristic of cancer cell is splitting limitlessly, never stopping, but normal cells will not grow limitlessly. Some reasons cause cancer cell " Crazy" ? Will " act in collusion with each other " in the cancer cell for German researcher's latest find, a kind of nucleoprotein and an enzyme ,Form and feedback the return circuit, encourage the cancer cell to split limitlessly. The researchers of Germany Munich university find, this is because one kind is called nucleoprotein of c-Myc and got rid of the controlling mechanism in cells, impel the cell division of cancer. This kind of albumen can regulate growth and division of cells, the gene which formates this kind of albumen should " work " in case of hematopoiesis, embryo's development,etc. ,Inhibited by cells when not needing " Have a rest " . However, this kind of gene gets rid of inhibiting from, expressing wantonly in the cancer cell, even acted in cancers such as lymphocytic cancer, breast cancer,etc. " Manufacturer " Role. Researchers find, enzyme SIRT1 that c-Myc protein highly gathered can activate a kind of old and feeble and death of inhibiting cells, and this kind of enzyme can act on c-Myc albumen instead, form a return circuit so, makes c-Myc albumen and SIRT1 enzyme more and more, impel the cancer cell to split limitlessly finally. Researchers say, find the return circuit of this feedback contributes to studying the new method to treat cancer. Block some or some several links in this return circuit by means of medicine,etc., perhaps can inhibit the cell division of cancer.


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