The cancer gene - switch molecule - synthetic for the first time Can control tumour to grow

The cancer gene - switch molecule - synthetic for the first time Can control tumour to grow
The cancer gene - switch molecule - synthetic for the first time Can control tumour to grow
In order to prevent tumour from growing to spread, the scientists are making great efforts from each route constantly. The scientific association for promotion of U.S.A., recent report of British Nature website, U.S.A. reaches an international joint research group of that rich cancer research institute of France to develop a molecule, can let, control genetic order of cancer fail, inhibit growth, cancer of tumour fundamentally. New research has been demonstrated a kind of protein can be sent out to the cancer gene " Stop " With " begin " Order, this kind of albumen is the apparent gene " read " The albumen is exactly a goal that the treatment of cancer aims at in the future too. In recent years, control behavioral research of the cancer gene to grow a lot, by controlling the method of the genetic switch to treat the cancer result obviously. Main author of thesis, reaching the rich cancer Braid, James of research institute of that law and receiving and saying, if can turn off the growth hormone gene of a cancer cell, cells will die. On the contrary, if open one and organize the gene normally, will let the cancer cell be turned into normal tissue cells. Whom they study have cancer of person who attack, namely children and young testis nucleoprotein centre line cancer (NMC) very much ,This is a kind of disease totally defined by the genetic characteristic - -BRD4-NUT genetic transposition. This kind of cancer is very obstinate, often happen on chest, head, neck,etc. along the body vertical centre line position, there is no effective therapeutic method in clinic yet. Chemotherapy is only valid in a short time, it is unable to prevent tumour from spreading finally. NMC cancer is by the chromosome " Replacement " Cause, two genes from different chromosome are linked together, such unusual amalgamation albumen is called BRD4-NUT. The genetic order in cells is just like one kind " The bookmark " ,The apparent gene on the base plate of chromatin is " Write " The albumen, another group of apparent genes can be compared to the rubber, is called " wipe and wipe " The albumen, can remove the bookmark. And the third kind of apparent genetic albumen, it can be " read " by one kind Order " bookmark " Albumen,it is thus genetic without being controlled switch, this exactly for goal that researcher aim at. Have, point out some the intersection of composure and medicine of type like getting stable at the scientific literature , general thiazole storehouse (Xanax) With hold in place with a net, end, fill half (Ativan) in Wait, can reduce the effectiveness of BRD4. Regard this as the clue, Braid receives and another researcher Qi Jun (transliteration) Develop a series of member, observe they could inhibit " read " of BRD4-NUT in the gene from Albumen. As a result, an association molecule has accomplished this, researchers name him as JQ1. This kind of equipment molecule is one set was assembled " The apparent genome " ,Can influence the multi-layer mechanism of cells, thus control the genetic behavior. It has two kinds of functions concurrently: First, lock the unusual albumen in NMC cancer cell, second, let them stop splitting up and duplicating, " forget " The identity of one's own cancer cell, resume into a look of normal cells gradually. They transplant NMC cancer cell on the little mouse of laboratory from patient, and used JQ1 molecule for some little mice. Braid receives and says, the result is very obvious, all little mice who has accepted JQ1 molecule treatment have lived, have not all died with JQ1. At present, Qi Jun and group are turning back the molecule shape, in order to give play to its greatest efficiency. Braid pays and still points out, because be able to deliver alternative molecule to the carcinogenic albumen, let them stop the cancer procedure, it is the lowest that this side effect has been brought down to. Develop JQ1 or this kind of molecule medicine, may produce the first individual that design for NMC patient specially to treat, also bring a new method for the anticancer treatment. (often beautiful monarch)


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