Study progress in disease reason

Study progress in disease reason
Study progress in disease reason
It is reported ' Reporter Nie SongYi) Recently, biological information science and technological dean, country's high-tech research development plan of medical university in Heilongjiang Province Harbin (" 863 " Plan) The research group which Professor Li Xia, person in charge of seminar, led, has established the adjustment relation of miRNA antithetical phrase thorough fare from the angle of overall importance for the first time, and developed the convenient, swift network analysis platform. The relevant thesis is published on the top magazine " news in brief of bioinformatics " in the field of bioinformatics published in the near future. MiRNA is not encoding RNA molecule of a single strand, the level adjusts and controls the expression of the gene after duplicating. MiRNA participates in a lot of important biological processes, such as development, splitting up, hyperplasia,etc.. Li Xia finds in previous research, the emergence of some diseases is not the whole biological thorough fare unusually due to, and may some area a certain of thorough fare even more ' Sub thorough fare) The function happens to lack proper care. Study further, Li Xia seminar recognises the sub thorough fare where 480 human miRNAs adjust and control at the system level for the first time, select the sub thorough fare that the function that miRNA adjusts and controls in coordination is relevant and form a cluster, and further investigate the adjustment characteristic of the relevant miRNA antithetical phrase thorough fare of cancer,etc. and 123 kinds of diseases. Brief result on,from in coordination with angle last miRNA to explain whether there aren't miRNA systematically not merely in the influence on adjusting and controlling in the sub thorough fare, also significant to studying the mechanism that microRNA contributes while disease takes place, develops.


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