The internal HIV's miracle disappears behind the leukemia man transplants the bone marrow

The internal HIV's miracle disappears behind the leukemia man transplants the bone marrow
The internal HIV's miracle disappears behind the leukemia man transplants the bone marrow
On December 7, Huaihua of Hunan, the earliest HIV-positive person in China cares about the centre - -Hongjiang district cares about the centre. Care about old Hong in in the center ' Assumed name) Making fun of child. Thunder Brown of Timothy (TimothyRayBrown) It must be the most noticeable patient in 2010. Everything about him is extremely mysterious, few people know the color of his hair, what pet family raises, where film star to like. Even so, in whole world media fall over each other, live in the intersection of Germany and white man 42 year old of Berlin by the intersection of report and this piece. He was once pestered 10 solid years by AIDS. On December 8, one is published the online thesis and claimed on the famous science magazine " blood " by seven people groups which the medical science department researchers of 3 universities of Germany make up, " our result of study proves this patient's AIDS has been cured " . Since HIV were discovered in 1981, in this one " century killer " The ones that reaches 60 million people chase and kill it in the list, perhaps Brown is not only first but also the only person cured at present. The recovery from illness of this German patient is considered as " The breakthrough progress of making people shake " . Have cured the AIDS miracle and taken place in the red building of a brick while treating leukemia, that is Charlotte hospital located in capital of Germany, it is the university hospital of the largest scale of Europe too. Brown is the old patient of this hospital. After diagnosed as AIDS 10 years ago, he has been accepting drug therapy here. The virus has not hit the health of this middle aged man, but been hiding in his body calmly all the time. AIDS Zhang LinQi, professor of comprehensive rearch centre seems in Tsing-Hua University, this is exactly HIV's frightening place. If regard cells as a national treasury, this kind of virus is just like a robber. This seems under the microscope it is just like one " The small thorn ball " Virus,will analyse and explain "national treasury" The gate " The safe password " ,Rush into cell inside. Then, it will enter one's own seal integration the most internal chromosome of cell, turn into a part of cells. Nowadays, people have been already no longer strange to the danger which this person who robs brought, it will attack the most important T4 lymphoid tissue in the human immune system. Once the immune organization collapses, resisting ability to change low of people, extremely infect the death probably. The persons who rob may hide for more than 10 years in patient's body. So work as people the medicine " police " While sending and entering the patient infected in the body, often difficult to capture these silently hidden scoundrels. Brown has been living under the shade of this group of robbers all the time. Meanwhile, another terrible disease entangles him silently. Several years ago, this unlucky man made a definite diagnosis of and suffered from leukemia. In two kinds " Hopeless case " Pincer attack under,seem,that the losings survive in nearly of hes possibility. However, base of a fruit of Ekkehard of clinician, director of Charlotte hospital, (EckhardThiel) Not giving up, this doctor who attacks hemology and oncology mainly decides to carry on a bold attempt. In the middle period of the 1990s last century, some scientists of U.S.A. once found, some people will not receive the infection of HIV innately. Base of a fruit and colleague of him begin, think in find a " receive the people infected with HIV innately " in the the intersection of bone marrow and donor of buying type with Brown ," after treating leukemia by bone-marrow transplantation, HIV in patient's body will disappear together accordingly too " ? In fact, in ordinary people's cell " national treasury " Outside, have mostly set up two " safe passwords " ,One is called CD4, another one is called CCR5. But for HIV, it is very easy for these two groups of passwords to analyse and explain, the so-called security protection measure performs practically no function. But is born HIV correctly in those " The immunity " Luck fellow cell at,because of gene mutation, it is CCR5 genetic code area take place in the amino acids No. 185 32 base lack. This kind is known as CCR5 32 defective genes are equivalent to encrypted for the national treasury, the robber no matter what kind of trick is used, it is unable to slip away to the national treasury. Brown is very lucky, in 60 are suitable for donor that Brown carried on bone-marrow transplantation, it has had CCR5 that research group has found one for him Person of the 32 type gene. In February of 2007, after Brown accepts the transfer operation, the donor's bone marrow begins in his internal operation, the new blood cell begins to be produced. Like what the doctors have ever thought in advance like that, cells produced newly have CCR5 32 defective genes. After the track investigation of more than 3 years, the doctors are sure a miracle took place, " HIV have totally disappeared in this patient's body " . Do not even dare to refer to this piece of everybody loudly " Cure " In the fields of two words, this is absolutely a discovery of awakening the deaf Just one year ago, the thesis written for this case is issued on the world medical circle famous " medical magazine of New England ". At that time, the from Germany research group say " controlled HIV for a long time through bone-marrow transplantation " carefully very . Zhang Lin Qi remembers, this case makes the whole science field " shock very much " . Before that thesis is issued, such terrible virus is called " pestilence of century after the history " . HIV are praised as the whole world " The No.1 infectious disease killer " ,2 million people die every year. World Health Organization writes articles and claims, if insist on treating in one's own official site too, "the people infected with HIV can keep the good state, keep labour capacity, lengthen the time of life, even the people infected with HIV in the low income countries can accomplish. " However, WHO likewise says resolute and decisively: "Infect and can't be cured HIV. " So, when Brown can not find the whereabouts of HIV again in body, Reuter wrote in the report, in this one " in everybody does not even dare to mention ' cures ' the field of two words loudly, this is absolutely a discovery of awakening the deaf " . Though this is one kind " It is unable to cure " Disease,but study on it have stranded. At present, the antiviral treatment can lengthen patient's life-span from 30 years to 50, more only 10 years ahead of time than the life expectancy that is totally cured. In the 1990s last century, what a great a proposition famous " drug cocktail therapy " is the scientist of Chinese origin ,Namely use odd kinds of medicines meanwhile, breed different links in cycle to HIV every medicine, thus achieve the goal of inhibiting or killing HIV. In November of this year, it is here that one is issued by research group of the branch school in San Francisco of University of California <>The thesis had claims, resisting may lower infection risk and spread speed of AIDS to a certain extent against duplicating virus medicines, "take medicines and reduce AIDS partly in man homosexuality and a pair of sex regularly in first identification of its? Row last Yu ���� of tool instrument 1 thumb to fetch thin? Once found in a forest Qi where U.S.A. served as assistant He Da one, though the medicine can inhibit new cells from being infected, still can live for a long time in the intersection of body and memory cell that infect already. The virus is hidden silently, cause medicines even unable to discover at all. This becomes " Radically treat the greatest obstacle of AIDS " . He likens HIV to " The superman in the microcosmos " ,Though the diameter is 100 nanometers short, it is an " awe-inspiring rival " . Several years ago, this one already and AIDS was beaten up to " returned in the sea " of the dealings of 19 years The professor decides to begin to develop vaccine of AIDS. Nowadays, in the animal experiment of the laboratory, vaccine has already produced " very good observation " . In July of this year, American national anaphylaxis and expert of research institute of infectious disease issued the research results on the " science " periodical, have called finding two kinds can " Tie it definitely " Attack, make a variation malicious antibody of by 90%% more than HIV. However, this does not mean vaccine will be put into production soon. Zhang Lin Qi says: "Though the direction is clear how far, no one knows. " After the news that Brown is cured spread, those once thought" this was that one was unable to radically treat disease " Scientist capital feel to be extraordinary it is excited. This has proved supposition before medical circle, " if utilized the genetic means to strike CCR532 base in the surface of cell, the infeted internal HIV might remove completely then. " Some scientists of America and Europe have already planned to encourage CCR5 The 32 type crowd donates the bone marrow, and look for the appropriate mixing type in the people infected with HIV of the whole world. They tell the desperate patient excitedly, " don't worry, AIDS can be cured " . The luck of duplicating Brown is difficult however, the luck wanted to duplicate Brown is not an easy thing. In the view of a forest Qi, the course that this German patient is cured, is just as " hit the little probability incidents of several times continuously by lightning " . A leukemia patient infected with by HIV, one, to HIV " immunity " Bone marrow mixing type,last wallets of fee medical, these key elements none of can be dispensed with. At least, it is very difficult for a Chinese patient to finish this, because have CCR5 in yellow little Person of the 32 type gene. In 100 European philtrums, only have a mutation gene of this kind of protection with extremely strong ability alone too. Medical association's former president American HIV pitches Georgia to think, " if turn this kind of method into a standard treatment, the risk exists greatly. " At present, the stem cell or bone-marrow transplantation is often used in the treatment of cancer, nobody knows healthy people if accept this kind of operation need bears the great danger. It involves utilizing the strong medicine and radiating things and destroying human body's original immune system, then input the donor's bone marrow, in order to make a new immune system again, and this kind of treatment and probably mortality of improvement of complication initiated. "This method not reality, and will probably kill people. " The adding Dr. Lip river and saying of human virus institute of U.S.A. Maryland university. 26 years ago, it was this scientist that found HIV together with his job partners. "I do not want to dampen the spirits on this interesting thing, however, as you know, this is an anecdote at most. Moreover until the fact that this person extremely, go on the detailed inspection, could totally confirm the virus has disappeared completely. " To a forest Qi, " scientific unpredictability is too great, some things look it is only interesting while beginning, but will probably bring milestone progress finally. " Once colleague Paxton is a good example. That virology family is a gay at the same time. In middle period of the 1990s last century, out of curiosity, he measured some homosexual friends' blood around oneself. The result makes people greatly surprised, some people are very easy to be infected by HIV, but another part will not be infected at all. The scientists have found CCR5 on the basis of Paxton's experiment 32. And exactly that experiment just carried on out of curiosity several decades ago, have rescued a life of German patient Brown. "It is put in right place in one step that scientific development is impossible, there may be very long ways before curing AIDS, but step out the first step at least now. " Zhang Lin Qi says. To this long-term professor engaged in HIV's research, this peculiar German patient has proved some at least, if can strike 32 bases which loses CCR5 in the body, radically treat the possibility of AIDS. "In the research of the fundamentals, plan not to happen to change fast forever, nobody can speak accurately, it is at the point of anything on earth, in which laboratory, this research will succeed. " He says conscientiously. (Zhao contains desert)


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