Discover some genetic mutations influence the ill risk of breast cancer

Discover some genetic mutations influence the ill risk of breast cancer
Discover some genetic mutations influence the ill risk of breast cancer
Www.xinhuanet.com Los Angeles 9 Cable of the 19th of moon (reporter's plateau) Studied to once find, genetic B R C A 1 related to breast cancer will improve the risk that women suffered from breast cancer notably while morphing. An international scientific research group led by U.S.A. Mayo Clinic says on a new British academic publication " natural science of heredity ", when a gene of B R C A morphs to make the risk that the woman suffers from breast cancer improve, the variation of other 5 genes will exert an influence on this risk. The related analysis of the whole genome that researchers carry on involves 20 research centers of 11 countries. First research object whether 1193 carry, make a variation gene and suffer from under the age of 40 women of breast cancer of soaking etc. by 1 B R C A. Researchers have analyzed about 55 ten thousand genetic mutations altogether in the above-mentioned woman's genome, then make a variation, compare and analyse with second all genetic mutations of research object these. The total number of person of the latter 1190, they carry, make a variation gene but suffer from of the same age women of breast cancer by 1 B R C A. Subsequently, researchers lessen the range of genetic analysis to many attitudes (S N P) of nucleotide of 96 forms ,And carried on the similar contrast in two bigger samples. Found finally, the variation located in 5 genes of 19 p 13 chromosome and some area, the probability that the women of the gene suffer from breast cancer of making a variation with carrying B R C A 1 is closely related with. Report to main copywriter, researchers of Mayo Clinic Dr. Fergus and Couch and say, this research results will help scientific research personnel to strengthen the initial cause of disease of breast cancer of understanding, and confirm and carry B R C A 1 in those and make a variation in the women of the gene, who suffers from breast cancer more easily.


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