Research reveals myocarditis is attacked by particular immune cells

Research reveals myocarditis is attacked by particular immune cells
Research reveals myocarditis is attacked by particular immune cells
March 29, research center, cancer of Germany, publish announcement, claim should the scientist find by cooperating with American colleague, myocarditis is attacked by particular immune cells to cause. Immune cell attack getting endogenous to organize, because they have no chance, discern one exist on the intersection of heart and protein in the muscle only in the ripe course. Myocarditis is usually very dangerous, often cause fatal cardiac enlargent. The heart transplant is that the only treatment hope under a lot of situations. For a long time, the doctors have already had evidences to show, one's own immunoreaction (namely the attack of the immune system) It is a reason for causing the dangerous inflammation. But is not clear so far whether antibodies or immune cells damage the heart muscular tissue yet. In addition, do not know either which some fatal attack of the immune system is directed against many kinds of proteins of heart muscle. Now, from coming from the research center of Germany's cancer, Harvard University, the intersection of U.S.A. and the intersection of cancer and the intersection of research institute,etc. and a plurality of scientific research group that scientist made up of research institution, uncle of NaFa, Dai untie these doubts and suspicions. The scientists little mouse with fatal myocarditis discovers, a kind of characterized myoglobulin �� - MyHC is the target that immune cells attack automatically in the little mouse heart. This kind of protein only exists on heart muscles, does not exist in skeleton muscles. Participating in the department of the research center of cancer of Germany of this research particularly, the triumphant professor of Sri Lankan says, such immune cells of T cell are while finishing its early development in the thymic organ, will meet a large number of cells, and think these cells are harmless. Ill experiment have �� - existence of MyHC in the little thymus of mouse, so, T cell have no chance to know this kind of protein in early days, meeting this kind of protein again will be thought it to be harmful and implementing the attack. Researchers still prove, make the thymus of the little mouse produce �� - MyHC through changing the hereditary gene, these little mice no longer suffered from one's own immunity myocarditis finally. Researchers say, people's thymus will not form �� - MyHC either. So, T cells circulated in people's blood continuously attack the potential possibility of the heart. The department teaches triumphantly in Sri Lankan and says particularly: "Once heart muscles are damaged because of the infection or myocardial infarction of a certain virus, a large amount of �� - MyHC will be released out, T cell will attack this kind of albumen and cause myocarditis. " This research results of the joint research group of Germany and the US contribute to researching and developing with more pointed myocarditis therapeutic method to one's own immunity. (reporter Li Shan)


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