Discover that inhibits living performance of the brain PKR molecule from improving memory

Discover that inhibits living performance of the brain PKR molecule from improving memory
Discover that inhibits living performance of the brain PKR molecule from improving memory
According to the daily scientific net recent report, the researchers of Beile medical college of American find, when a kind of molecule activity which is called PKR in little mouse brain is inhibited, they behave more splendidly in view of study and remembering, memory ability of improving people that therefore may develop PKR mark medicine. The relevant thesis is issued on the recently the first stage of " cell " magazine. " people only know PKR molecule (RNA of the double-stranded structure activates protein kinase) It is the receptor that a kind of virus infects, still know nothing about their role in brain. " Say in thesis senior author, nerve not Casta - Mattie of Lip river of scientific associate professor of Beile medical college, but change in the activity of PKR is disorderly in various cognition. The research group has inhibited PKR in the little mouse brain with genetic technology, then train they and little normal mouse to look for the platform in the round swimming pool. Found finally, this kind of mouse seemed to have in various behavioral experiments" superly " Memory. Explain in Casta - Mattie: "We find that inhibit PKR from strengthening the excitability of the brain cell, make study and memory ability of these little mice improve. The little mouse makes use of visual clue to look for the platform hidden in the round swimming pool, this is a kind of space memory, it is place and incident as to mankind. In the experiment, the little normal mouse must remember the position of platform in a lot of days through training repeatedly many times, so long as training can be learnt and lack the little mouse of PKR. " They have further studied the operation of this kind of molecule course, find when PKR is inhibited, interferon of �� (a molecule related to immunity) Will improve and touch suddenly actively, strengthen the information interchange between the neuron. Think traditionally, these two kinds of molecules is infected with and works in immunoreaction only in the virus. "Have never expected they adjust and control the brain related to taking shape in memory for a long time and move about yet, play an important role in studying how to keep memory, form new memory more permanently. " Say in Casta - Mattie. In addition they also find, PKR inhibitor (a little molecule that can lock PKR activity) Also can imitate this course, so can strengthen medicines as a memory. "This really makes people shocked, we can improve memory and brain activity at the same time with the special PKR mark medicine. But should turn this into effective treatment, need studying more. " Say in Casta - Mattie. They will improve the human brain function with these discoveries next, the person dropping to those memory brings good news. (often beautiful monarch)


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