The basic research of bird flu obtains multiple original achievements

The basic research of bird flu obtains multiple original achievements
The basic research of bird flu obtains multiple original achievements
It is reported ' Reporter Wang Dan) Great project of the national natural science fund - -Study and finish forming the question to confirm in Beijing a few days ago in key basic sciences problem of bird flu. The expert evaluates the group thinks, this project is at bird flu virus molecule epidemiology, the intersection of virus and the intersection of albumen and structure and function, infect mechanism and immunity reply and bird flu virus infect characteristic and the intersection of spread and the intersection of route,etc. and respect of people make the original result, have offered the new thinking for further developing the reseach, medicine of basic research of influenza, influenza vaccine. It is introduced, this research project is divided into 4 subjects together, include epidemiology with virus, member of bird flu virus, evolve law of making a variation, structure and function of bird flu virus main albumen are studied, people infect with the intersection of bird flu virus and the intersection of mechanism and research and immunity that bird flu virus infect reply with the immunity protecting the mechanism, studying, presided over by the high good fortune researcher of Ins of Microorganism,Academia Sinica. Go through, study 4 year, seminar expound influenza virus to evolve law of making a variation in recent years; Have analyzed the structure of some inferior bases of H5N1 virus RNA polymerase, has offered the potential new target to click in order to resist the drug design of influenza virus; Have reported it causes the skin cells on people's lung to bite by oneself that influenza virus is infected for the first time, find that can inhibit the duplication of influenza virus biting inhibitors; Have appraised the first H5N1 virus CTL table location with biological function; Design and select a kind of poly- inhibitor that can inhibit membrane of influenza virus from merging; Have found H5N1 virus can carry on mother-to-baby transmission through the placenta, people's intestinal cells have bird flu virus �� - 2, saliva sour receptor of 3 galactose glucoside. This project publishes 49 theses together, 2 among them are published in internationally recognized magazine " Nature ", one is published in " lancet ". Patent 13 items together, among them 1 international monopoly.


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