Rheumatoid and arthritis are expected to manage one from the source

Rheumatoid and arthritis are expected to manage one from the source
Rheumatoid and arthritis are expected to manage one from the source
It is reported ' Reporter Li TianShu) Our country verifies it is expected to be used in the the treatment of rheumatoid arthritis that the antigen changes and constructs peptides for the first time. Recently, Peking University the intersection of the People's Hospital and the intersection of rheumatism and immune chestnut, Professor of department, account for this research results that the country heads the list of signers and obtain China's medical scientific award second prize in 2007. The chestnut takes the country to point out, antigen become construct peptide can prevent rheumatoid from by inhibiting the recognition of the pathogenic antigen of T cell and is applied arthritis patient unusual pathology react emergence in the body, thus the initial links that have illness coming on at rheumatoid and arthritis are treated. Rheumatoid and arthritis regard occuring frequently destructive arthritis as main clinical manifestation. Up until now, still have no way of inhibiting the therapeutic method that this disease, condition develops essentially both at home and abroad. The chestnut takes country's seminar in the national natural science fund key item, " 863" Under the support of funds such as the project, mainly explore the molecule of rheumatoid and arthritis has illness coming on in mechanism and poly- immunization therapy. This finding for the past 10 years, the course that rheumatoid arthritis antigenic polypeptide and specific T cell discern each other can be turned into and construct peptide competitiveness to inhibit by the antigen, prevent one's own immunity of the low reaches from replying, and then inhibit and lighten immunity and inflammation of rheumatoid and arthritis to damage. Such non- antigen is turned into constructing peptides to pass and inhibit pathogenic antigen activatory function to immune cell, the initial links from rheumatoid and arthritis inhibit the pathologic course of this disease can reach " Get a permanent cure " Purpose. Such new polypeptide can that the interference is similar to main pathogenic antigenic structure the combination of many kinds of antigen and immune cell also. So, can prevent the pathogenic function of rheumatism arthritis target antigen of many kinds. At present, the treating of the external rheumatoid and arthritis in our country relies mainly on treating to the ill and attempting to lighten the joint causing therefrom and corroding. The chestnut accounts for country,etc. and focuses on the initial links that rheumatoid and arthritis have illness coming on for the first time, inhibit the pathogenic antigen from starting function in causing a disease through the specificity, prevent unusual immunoreaction pointedly, can reach better curative effect and reduce the bad reaction. Dr. Li Ru of this seminar introduces, the turning into constructing osseous destruction and joint deformity that peptides can obviously inhibit arthritis from causing of such non- antigen, and reduce the pathogenic molecule in serum.


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