Study and obtain the break-through in biological treatment of rheumatoid and arthritis

Study and obtain the break-through in biological treatment of rheumatoid and arthritis
Study and obtain the break-through in biological treatment of rheumatoid and arthritis
It is reported recently, PLA man 307 hospital immunology lab and national biomedical the intersection of analysis center and immunity analyze experiment chief of the office seminar that Xi YongZhi researcher head for 10 to exert Tackle key problems, succeed in developing first all new therapeutic genetic vaccine because of the different kind of �� type collagenic genes in the world in strength, this is that our country treats the great breakthrough that the research field obtains at rheumatoid and arthritis and living beings. Rheumatoid and arthritis are driven and lain between whole body one's own immune disease led by CD4 +CD28 +Th1 cells of a kind of antigen, and the Model �� glue principle is one of the most key one's own antigen of this disease, can find resisting �� type collagenic antibody and one's own reactive T cell of a large amount of in the patient's serum and synovial cavity. Since the 1990s of last century, have explored the immunization therapy tactics that rheumatoid and arthritis are new in the world, however, explore that is used for therapeutic vaccine of rheumatoid and arthritis being only limited to T cell vaccine or T cell peptide vaccine in the world at present, there is not therapeutic vaccine directed against the specific antigen yet. The seminar that researcher Xi YongZhi headed has launched the exploration of new treatment vaccine originally, tolerate, go on with gene therapy the intersection of vaccine and two major tactics fully organic to merge oral immunity. Through tackling key problems for a long time, the seminar clones and succeeds in encoding CCOL2A1 total length cDNA and genome DNA for the first time in the world, have established the solid foundation for new DNATolerizing therapeutic vaccine which developed rheumatoid and arthritis. Relevant research results are issued on academic periodicals such as " gene ", " member's immunology ",etc. separately. (Zhang Guoqing)


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