Rheumatoid and arthritis will be diagnosed in early days or there will be new marks

Rheumatoid and arthritis will be diagnosed in early days or there will be new marks
Rheumatoid and arthritis will be diagnosed in early days or there will be new marks
It is reported ' Reporter Li TianShu) A few days ago, it verified, a kind of new mark was expected to be used in the diagnosis in early days of rheumatoid and arthritis that the People's Hospital of Peking University studied. Research results this issue in latest one at " whether rheumatism learn the magazine ". Rheumatoid and arthritis are a kind of common chronic disabling one's own immune disease, the destruction of the slippery membrane of joint is having illness coming on for 3 months and can present. Treat while being regular, 75% patient can present the intersection of joint and deformity within 3 years. It helps to delay condition progress to diagnose and treat in early days, improve patient's prognosis. In recent years, the discovery of many kinds of new one's own antibodies has offered the important means for the fact that rheumatoid and arthritis are diagnosed in early days. But because diagnose sensitivity and peculiar degree are not very ideal, researchers need to find the new mark urgently. Clinical at present in early days the diagnosis index is mainly a rheumatoid factor (RF) With the second generation of resisting the citrulline of ring poly- ( CCP2) Antibody. There is the report that points out, resist the mutation type citrulline protein of wave form (MCV) in serum May become the new diagnosis mark of rheumatoid and arthritis, but not been verified in the Chinese crowd yet. For this reason, researchers such as the rheumatism immune Dr. Liu Xia of department of the People's Hospital of Peking University,etc., it is smaller than the early rheumatoid arthritis patient, 60 normal person and 76 other disease patients for one year as the research object to choose 170 courses of disease at random, have measured and resisted MCV antibody level, resisted CCP2 antibody and RF in serum, and appraise the diagnosis results of these 3 kinds of diagnosis indexes. Study to reveal, the sensitiveness in the arthritis group of rheumatoid is 78.2%, 61.8% and 72.4% respectively to resist MCV antibody, resist CCP2 antibody and RF in early days, the specificity is 93.4%, 96.3% and 80.1% respectively. Resisting MCV antibody will have supreme sensitiveness and higher specificity to the diagnosis of early rheumatoid and arthritis. Researchers jointly detect and study briefing to two of 3 kinds of diagnosis indexes on, resist MCV antibody and resist CCP2 antibody to jointly detect most high peculiar degree ' 97.8%) With the supreme sensitivity ' 81.2%) . Researchers draw the conclusion in view of the above, it is the sensitive index that early rheumatoid and arthritis diagnose to resist MCV antibody. If jointly diagnose with resisting CCP2 antibody, can improve the examining rate early of rheumatoid arthritis.


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